Uryū Ishida vs. Mayuri Kurotsuchi

Uryū Ishida vs. Mayuri Kurotsuchi is Ishida's second fight during the Ryoka Invasion of Seireitei. Uryū Ishida and Orihime Inoue are separated from the others and therefore begin to look for the others from their group as well as for Rukia Kuchiki whom they have come to rescue. As they hide in the shadows and move towards their destination in order to avoid unnecessary fights they are detected by the 12th division Captain as well as the 2nd President of the Shinigami Research Institute, Mayuri Kurotsuchi.

They dress themselves as Shinigami and begin their search in the darkness of night but are met by Makizō Aramaki of the 11th division and are interrogated by him, asking them the division to which they belong. Ishida and Inoue answer that they are from the 11th division but Aramaki unable to recognize them checks Inoue's uniform and asks them why they are wearing 12th division uniforms and why were they walking without their Zanpakutō's.

A group of Shinigami interrupts him and tells them that they would escort them to the squad's barracks. However the 12th division Captain Mayuri Kurotsuchi appears and blows the group up as they were a part of his plan to trap Ishida and Inoue. Inoue protects Ishida, Aramaki and herself with her shield of the Six Flowers of the Hibiscus Shield. Mayuri is intrigued by Inoue's powers and makes a proposition with her asking her to be a research subject but Ishida tells her to run away and when she denies he orders Makizō Aramaki to take her along with him and run away. He stays back to fight Mayuri Kurotsuchi.

Battle
Uryū Ishida slices off Mayuri Kurotsuchi's arm off as the latter tries to reach for Orihime Inoue but he quickly regenerates himself. Ishida then uses Hirenkyaku to get behind Kurotsuchi but he is overwhelmed by the 12th division captain who uses his Zanpakutō Ashisogi Jizō's Shikai to paralyze his left arm leaving him unable to use his Quincy Bow & Spirit Arrows. He uses his own lieutenant Nemu Kurotsuchi to divert Ishida, slicing her too and kicks her when she asks for medication to help her breathe. This angers Ishida but Kurotsuchi shrugs him off as the "Quincy Pride" they were so proud of even at the edge of death. Saying this he recalls his last Quincy research subject who kept calling his pupil or grandson's name and shows Ishida the picture who is apparently the latter's grand father. An enraged Ishida vows to avenge his grandfather and sensei and to kill Mayuri Kurotsuchi. He uses the Ransōtengai to reattach his paralyzed arm using bundles of Spirit threads to forcibly use the arm like a puppet.

Mayuri applauds him for being able to use such the technique at such a young age. Ishida then tells Mayuri that he would kill him for the sake of the same "Quincy Pride" that he was making fun of and takes off his Sanrei glove to attain the pinnacle of Quincy power, the Quincy Final Form at the cost of losing all his Quincy power after having used it. Intimidated by the vast Reiatsu emitted by Ishida, Mayuri releases his Bankai, Konjiki Ashisogi Jizō and proceeds to poison him along with his lieutenant with his Bankai. Ishida is bewildered at first seeing Mayuri Kurotsuchi's Bankai and Mayuri then tells him that every Zanpakutō has two stages that can be released, the first is the Shikai and the second,the Bankai. He then proceeds to attack Ishida and his Bankai hurls forward at a crushing speed. However, Ishida releases his arrow and shoots it right through Mayuri Kurotsuchi's Bankai all the way through Mayuri himself blowing a hole in his midriff. But Mayuri stabs himself with his own Zanpakutō and changes himself into a liquid state and hence escapes, saying that he can not be killed in this form.

Aftermath
Mayuri Kurotsuchi escapes but is unable to get back to his normal self for several days. Uryū Ishida is poisoned but Nemu Kurotsuchi offers him an antidote for the poison as a sign of gratitude for sparing her Captain as well as father's life. However, Ishida loses his Quincy powers after achieving the Quincy Final Form for a fleeting moment.