Board Thread:General Discussion/@comment-4317207-20130313085814/@comment-8986886-20130604015455

Noblebauer wrote: If they both have Quincy blood and Juha was the first Quincy, then yes, they are related. Just not closely... Some foreshadowing to this conclusion is from statements made by Ichigos friends. In the very first arc, Keigo and Orihime state that they are very similar. Must be the Quincy blood that makes one short tempered. ^_^

Yhwach is well over a thousand years old; that means around 50 generations separate him from Ichigo and Uryu; I'd say their blood relation is rather thin by now...