Uryū is Attacked, A Threat Draws Near the Friends!

 is the three hundred and forty-fifth episode of the Bleach anime.

After Ichigo and Orihime visit Uryū in hospital, Keigo and Asano are attacked.

Quincy Encyclopedia
Ryuken states that his long awaited arrlval in the main storyline has put him behind his office work. But then, he is startled by Isshin from behind, who is welcoming him back. Ryuken then asks why is he always in his office, with Isshin replying that he has nothing to do. Ryuken then tells Isshin that isn't he also a doctor too, which Isshin responds by yawning. This irritates Ryuken, who proceeds to summon his bow and aim an arrow at him, as well as stating that he only examined a patient once in the main storyline (when Sado was attacked by a Hollow). Isshin then gets up and says that it is irrelevant, to which Ryuken asks him to shut up and proceeds to fire his arrow at him, which causes an explosion in the hospital.