User blog comment:Xilinoc/Everything but the Rain op. 8 - "The Defenders"/@comment-5675229-20130424190706

If being attacked by a Hollow caused Masaki to be like this, and if Isshin stops "Soul Suicide" from happening at the cost of his powers, then this (might) explain something that happened later. Masaki (she is still a Quincy, no?) is attacked by Grand Fisher due to Ichigo being spiritually aware. She survives, but Soul Suicide occurs because she was attacked by a Hollow.

Sounds like crazy speculation, I know.