Board Thread:Questions and Answers/@comment-1412197-20150129020741/@comment-10330822-20200727190757

You'd think they'd just have Orihime used her rejection ability on it, since it was already heavily implied that her powers could affect the object. The Hogyoku itself seems indestructible, which is why you'd need to hide it within a soul like Urahara did, or reject its existence entirely, in essence reversing its very existence to the point it didn't exist.